Ian Bell and Tim Ambrose make their final appearances for Warwickshire before joining the England squad for the first Test, which starts on May 15.
Warwickshire retain the same squad which drew with Leicestershire last week, with Lee Daggett looking to force his way into the line-up.
Ambrose made a fine unbeaten 156 in that game, but Tony Frost can expect to take the gloves in the next first-class match against Cambridge UCCE at Fenner's, if Ambrose is called up to the squad for Lord’s as expected.
Navdeep Poonia also takes his place in the second XI after scoring 75 for Scotland in the Friends Provident Trophy match on Sunday.
Naqqash Tahir (shin splints) and Jim Troughton (back) continue their rehabilitation in the second-string, who play Surrey at Cheam.
Charl Langeveldt should make his LV County Championship debut for Derbyshire.
The South African fast bowler was signed under the Kolpak ruling and has starred in recent Friends Provident Trophy matches for his new county.
But Derbyshire will be without two of their key all-rounders, Graham Wagg, through illness, and Greg Smith, who has torn a muscle in his arm.
Wagg’s absence could open up a spot for fellow left-arm medium-pacer Kevin Dean, who has been struggling with a knee injury in the early part of the season.
Tim Ambrose will be looking to take his form into the first Test