Keith Barker continued his habit of performing well against Durham when he took 4-41 to help dismiss the hosts for 267 on the first day of the LV= County Championship match at the Emirates Durham ICG.
Warwickshire, who closed on 31 for one in reply, will surely have been the happier of the two teams at stumps after losing the toss.
The reigning champions are seeking only their second win of the season, the first having come against Durham at Edgbaston in April.
Barker, who took four wickets in that game and returned a career-best match haul of 10-70 against Durham last summer, struck with the second ball of the day when Mark Stoneman edged behind to Tim Ambrose.
The left-arm swing bowler snared the other opener, Keaton Jennings, shortly after lunch. The former South Africa Under-19 captain spoiled the hard work which had taken him to 33 by hooking to long-leg.
Four of the top five reached 30, but only Ben Stokes progressed to a half-century, which he completed off 92 balls by pulling Jeetan Patel for six.
The off-spinner had his revenge when he persuaded Stokes to play on for 61, giving him his third wicket after he had sparked Durham's slide from 163 for three.
Patel finished with 3-68 and should have had a fourth wicket as he saw Mark Wood dropped at slip on nought by Rikki Clarke, the other successful bowler with 3-37.
Clarke did more bowling than he might have expected as Boyd Rankin, who had extracted steep bounce earlier in the day, missed the final session through illness.
Durham’s middle-order collapse started when Will Smith edged Patel to slip after making 45.
Paul Collingwood and Phil Mustard then fell in successive overs. The captain was caught off bat and pad at silly mid-off for one and Mustard went for a duck when he played defensively forward and edged Clarke low to first slip.
Wood and Graham Onions put on 43 before Barker returned with the new ball and took the last two wickets with successive deliveries.
He swung one through Wood's defences to bowl him for 22, while Chris Rushworth drove at a wide one and nicked through to Ambrose.
The ease with which Onions made an unbeaten 22 suggested Durham's total was below par and this seemed to be confirmed when Varun Chopra pulled the England seamer for six on his way to 24 not out.
Chopra’s partner, Ian Westwood, fell for five in the final over when he miscued a pull off Onions to mid-on.