The England captain hit 129, and combined in a 226-run opening stand with Tammy Beaumont, to inspire Kent to a thumping 173-run win over Yorkshire on Sunday.
Megan Belt then claimed 3-12 as Yorkshire were bowled out for 92 in 30.3 overs.
Kent made it two wins from two the next day as Middlesex were beaten by 34 runs.
Beaumont this time top-scored with 53, following her 86 against Yorkshire, while Laura Marsh also posted a half-century in a total of 231 for nine.
Middlesex made a good fist of the chase with Natasha Miles hitting 68 at the top of the order, but they were eventually bowled out for 197 in 46.3 overs.
Defending champions Sussex and Surrey also enjoyed a pair of wins to start the season.
Sussex beat Essex by nine wickets in the opener before another confident display saw them defeat Warwickshire by eight wickets.
Surrey had to work harder for their unblemished record as they first beat Warwickshire by 16 runs, before Yorkshire came within eight runs of victory.
Bryony Smith’s unbeaten 60 from 42 balls proved crucial in the win over Yorkshire as she took the lead role in a 28-run stand for the last wicket with Beth Kerris.
Opener Lauren Winfield hit 78 in pursuit but Yorkshire fell short at 215 for eight.
Berkshire snuck a one-run win in their only game on the opening weekend against Nottinghamshire.
Skipper Heather Knight made a duck but Fritha Morris’ 3-17 helped Berkshire just defend 141.
Notts bounced back from that tight reverse to overcome Essex by eight wickets. Amy Gauvrit starred with 6-24 - after grabbing 4-7 against Berkshire – as Essex were bowled out for 93.
Sonia Odedra led the chase with 44 after she had also claimed 3-19.
In Division Two, Lancashire were the only county to secure a pair of wins to start their campaign.
Ashes winner Kate Cross claimed 4-29 in a six-wicket win over Ireland before Somerset were beaten by eight wickets.
Wales and Devon won their only games of the weekend. Wales beat Durham by six wickets while Devon were comfortable 167-run winners over Staffordshire.
Northamptonshire took the early lead in Division Three with wins against Scotland and Derbyshire.
Gloucestershire won their only game, on Monday, by 25 runs against Oxfordshire, who had overcome Hertfordshire by five wickets the previous day.
Suffolk, Norfolk and Cumbria all started with wins in Division Four.