South Africa responded to their first Test defeat in almost two years by dominating the opening day of the second encounter in Dubai.
Having emerged victorious at Abu Dhabi's Sheikh Zayed Stadium by seven wickets, the hosts folded to leg-spinner Imran Tahir as battle was renewed at the Dubai International Cricket Stadium.
Tahir, who ended his last five-day appearance with awful match figures of 40-1-260-0 against Australia at Adelaide, showed great variation to claim 5-32 as Pakistan were dismissed for just 99.
Their misery was then compounded as Graeme Smith’s unbeaten 67 led the Proteas to 128 for three at the close, a lead of 29.
Even that effort, though, could not take the spotlight off Tahir.
Helped by Dale Steyn ousting Khurram Manzoor and Morne Morkel dismissing Azhar Ali, he claimed three priceless wickets on the stroke of lunch.
Shan Masood inside-edged on to his stumps, Misbah-ul-Haq was bamboozled and trapped lbw by a googly and Adnan Akmal castled by a quicker ball.
To make matters worse for Pakistan, Steyn struck again between those breakthroughs when having Younus Khan caught behind.
From 60 for six at lunch, the hosts - who chose to bat - did not manage a riposte as Tahir and Co finished the job.
Smith, well supported by Alviro Petersen’s 26 and Dean Elgar’s 23, led the way thereafter as South Africa assumed control.
The only disappointment for the tourists was Jacques Kallis, enduring a poor run of late, falling lbw to Saeed Ajmal - who ended with figures of 2-42 - for just seven.