Six wickets for Chris Rushworth and a century by Scott Borthwick put Durham in a position of total command on the second day of their LV= County Championship match against Derbyshire at the Emirates Durham ICG.
After dismissing Division One's bottom club for 113, Durham reached 208 for two in their second innings to lead by 348.
Keaton Jennings made his second fifty of the match and remained unbeaten on 65 after sharing a stand of 168 with Borthwick.
Resuming on 15 for one, the visitors never recovered from losing lost two wickets in the day's first eight balls.
Durham’s seamers produced some excellent swing bowling in the baking heat and the only lengthy resistance came from Shivnarine Chanderpaul, who batted for 103 minutes for 14.
Rushworth swung one in to take out Richard Johnson's off stump in the first over and went on to collect figures of 6-64.
Wayne Madsen tried to turn Callum Thorp's second ball of the day to leg and gave the first of four catches to wicketkeeper Phil Mustard.
Thorp also had Dan Redfern caught at first slip in recording figures of 11-5-11-2, then Mark Wood struck in his second over when Tom Poynton edged a drive.
Ben Stokes troubled Chanderpaul more than anyone, but it was Rushworth who removed him with the third ball of his second spell. The West Indies batsman made a very late decision to play and edged to Mustard.
Two balls later Jonathan Clare wafted loosely to be caught at gully, completing Rushworth's second five-wicket haul of the season.
Derbyshire were 81 for eight at lunch, needing 23 to avoid the follow-on, and Rushworth had 5-39 at that point. He came under fire for two overs before taking the final wicket when he bowled Mark Footitt for 16.
Mark Stoneman, captaining Durham in the absence of Paul Collingwood with a thumb injury, fell lbw to Tim Groenewald for 10 when shouldering arms.
But Derbyshire began to look demoralised as Borthwick raced to 50 off 48 balls, pulling powerfully as he took advantage of too many short balls.
He reached a 117-ball century with a six pulled over midwicket off left-arm spinner David Wainwright, but departed for a career-best 117 when he was lbw on the back foot to the off-spin of Redfern.