Wyatt’s 72 from just 54 balls set the hosts up for a score of 139, which they comfortably defended as South Africa’s innings ran out of steam.
After the Proteas won the toss, Wyatt shared an opening partnership of 108 with Laura Marsh, who made 39, and smashed nine boundaries as she raised an impressive half-century.
Amy Jones and Fran Wilson added some late runs after Wyatt fell in the 18th over, to give the academy a good score of 139 for two.
The early wicket of Dane van Niekerk from Freya Davies gave the academy the best possible start and, despite an unbeaten half-century from Trisha Chetty, South Africa were never in the hunt.
Sonia Odedra, Marsh and Georgia Hennessy were all economical and picked up wickets at crucial moments as South Africa finished 25 runs short on 114 for five.