India batted first at the Narendra Modi Stadium and made 146-9 from their 20 overs. Yogendra Bhadoria top scoring for the hosts with 31. There were two wickets apiece for England's Daniel Reynaldo, Anthony Clapham and captain Callum Flynn.
In reply England made 97 before being bowled out in the 18th over. Angus Brown leading the run scorers for the visitors with 25 to his name.
England next face India at the same venue on Tuesday.
After the match captain Flynn gave his thoughts "We are very disappointed in the end result, but we are not panicking. We know how tough it is to win in India and we are determined to make things right after today’s disappointing batting performance.
"The first innings was nearly perfect, we executed our plans 90% of the time and kept them below par. We were really confident going into the changing rooms at the break. One of the things we talk about is taking three wickets in the powerplay because stats show if you do, you often win games more often than you lose. So losing five wickets when we batted in the powerplay really went against everything we had worked on.
"The boys are very disappointed of course, but this is a special group with some great personalities, so we are already excited to get going again on Tuesday."
England Men's Physical Disability Team India Tour Fixtures
Sunday 28 January, India won by 49 runs
Tuesday 30 January, India v England, Narendra Modi Stadium, 10am
Thursday 1 February, India v England, Gujarat College, 10am
Saturday 3 February, India v England, Railway Ground, 10am
Tuesday 6 February, India v England, Narendra Modi Stadium, 10am